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Bone SPECTCT_GE_JNM200702_ Nononcologic Patients Referred for Bone
SPECT/Multislice Low-Dose CT: A Clinically
Relevant Constituent in the Imaging Algorithm
of Nononcologic Patients Referred for Bone
Scintigraphy
Einat Even-Sapir1,2, Gideon Flusser3, Hedva Lerman1, Gennady Lievshitz1, and Ur Metser1,2
1Department of Nuclear Medicine, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; 2Sackler Faculty of Medicine, Tel-Aviv University,
Tel-Aviv, Israel; and 3Musculoskeletal Radiology Unit, Department of Radiology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel
The purpose of this prospective study was to assess the role
of SPECT/multislice low-dose (Msl) CT as a constituent in the
imaging algorithm of nononcologic patients referred for 99mTc-
methylene diphosphonate bone scintigraphy (BS). Methods:
SPECT/CT was performed using a novel hybrid system, which
incorporates a g-camera and a multislice low-dose CT, on 76
consecutive nononcologic patients with nonspecific scinti-
graphic findings, which required further correlation with morpho-
logic data. Results: SPECT/MslCT was of added clinical value in
89% of the patients. Characterizing scintigraphic lesions by their
morphologic appearance, SPECT/MslCT reached a final diagno-
sis in 49 of 85 (58%) nonspecific scintigraphic bone lesions found
in 59% (45/76) of patients, obviating the need to perform addi-
tional imaging. In another 30% of patients (23/76), SPECT/MslCT
data optimized the patients’ imaging algorithm as the perfor-
mance of a full-dose CT, MRI, or labeled-leukocyte scintigraphy
as the next imaging was based on its findings combined with the
patient’s clinical presentation. Conclusion: SPECT/MslCT is a
clinically relevant constituent in the imaging algorithm of nonon-
cologic patients referred for BS.
Key Words: fusion; SPECT; CT; SPECT/CT; bone
J Nucl Med 2007; 48:319–324
Most published data on the role of hybrid imaging of
PET or SPECT and CT has been dedicated to oncologic in-
dications, probably because CT is a common constituent in
the imaging algorithm of cancer p
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