Plasmid Mediated Quinolone Resistance a Multifaceted Threat.pdf

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Plasmid Mediated Quinolone Resistance a Multifaceted Threat.pdf

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Plasmid Mediated Quinolone Resistance a Multifaceted Threat

CLINICAL MICROBIOLOGY REVIEWS, Oct. 2009, p. 664–689 Vol. 22, No. 4 0893-8512/09/$08.000 doi:10.1128/CMR.00016-09 Copyright ? 2009, American Society for Microbiology. All Rights Reserved. Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat Jacob Strahilevitz,1* George A. Jacoby,2 David C. Hooper,3 and Ari Robicsek4 Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University, Jerusalem 91120, Israel1; Lahey Clinic, Burlington, Massachusetts 018052; Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 021143; and Department of Medicine, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois 602014 INTRODUCTION .......................................................................................................................................................664 PENTAPEPTIDE REPEAT PROTEINS..................................................................................................................665 Discovery of qnr Genes...........................................................................................................................................665 qnrA.......................................................................................................................................................................665 qnrS .......................................................................................................................................................................665 qnrB.......................................................................................................................................................................666 qnrC.......................................................................................................................................................................666 qnrD .................................................................