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polymer-xerogel composites for controlled release wound dressing.pdf

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polymer-xerogel composites for controlled release wound dressing

lable at ScienceDirect Biomaterials 31 (2010) 6336e6343Contents lists avaiBiomaterials journal homepage: www.elsevier .com/locate/biomateria lsPolymerexerogel composites for controlled release wound dressings Marius C. Costache a,1, Haibo Qu b,1, Paul Ducheyne b,*, David I. Devore a,2 aNew Jersey Center for Biomaterials, Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA bCenter for Bioactive Materials and Tissue Engineering, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USAa r t i c l e i n f o Article history: Received 2 April 2010 Accepted 29 April 2010 Available online 26 May 2010 Keywords: Composite Wound dressing Solegel Polymer Controlled drug release* Corresponding author. E-mail address: ducheyne@ (P. Duc 1 Both authors contributed equally. 2 Current address: US Army Institute of Surgical R 78234, USA. 0142-9612/$ e see front matter 2010 Elsevier Ltd. doi:10.1016/j.biomaterials.2010.04.065a b s t r a c t Many polymers and composites have been used to prepare active wound dressings. These materials have typically exhibited potentially toxic burst release of the drugs within the first few hours followed by a much slower, potentially ineffective drug release rate thereafter. Many of these materials also degraded to produce inflammatory and cytotoxic products. To overcome these limitations, composite active wound dressings were prepared here from two fully biodegradable and tissue compatible components, silicon oxide solegel (xerogel) microparticles that were embedded in tyrosine-poly(ethylene glycol)-derived poly(ether carbonate) copolymer matrices. Sustained, controlled release of drugs from these composites was demonstrated in vitro using bupivacaine and mepivacaine, two water-soluble local anesthetics commonly used in clinical applications. By systematically varying independent compositional parame- ters of the composites, including the hydrophilic:hyd