Ron knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer.pdfVIP

Ron Knockdown and Ron Monoclonal Antibody IMC- RON8 Sensitize Pancreatic Cancer to Histone Deacetylase Inhibitors (HDACi) Yi Zou, Gillian M. Howell, Lisa E. Humphrey, Jing Wang, Michael G. Brattain* Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America Abstract Recepteur d’origine nantais (Ron) is overexpressed in a panel of pancreatic cancer cells and tissue samples from pancreatic cancer patients. Ron can be activated by its ligand macrophage stimulating protein (MSP), thereby activating oncogenic signali