Shortapplicationsofverylow-magnitudevibrationsattenuat.docVIP

新疆中医医院医学统计咨询室制 第 PAGE 10页 共 NUMPAGES 10页 CONSORT 清单评价RCT论文 论文 部分条 目内 容评 价VAS文题 摘要1a文题能识别是随机临床试验short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest是1b结构式摘要，包括试验设计、方法、结果、结论几个部分BACKGROUND CONTEXT: Loss of functional weightbearing during spaceflight or extended bed rest (BR) causes swelling of the lumbar intervertebral discs (IVDs), elongates the spine, and increases the incidence of low back pain (LBP). Effective interventions for the negative effects of unloading are critical but not yet available. PURPOSE: To test the hypothesis that high-frequency, low-magnitude mechanical signals (LMMS) can attenuate the detrimental morphologic changes in the lumbar IVDs. STUDY DESIGN/SETTING: Volunteers were subjected to 90d of BR and 7d of reambulation. While retaining this supine position, 18 random subjects received LMMS (30 Hz) for 10 min/d, at peak-to-peak acceleration magnitudes of either 0.3 g (n5 12) or 0.5 g (n 56). The remaining sub-jects served as controls (CTRs). PATIENT SAMPLE: Eighteen males and 11 female (3367 y) healthy subjects of astronaut age (35 6 7 y, 18 males, 11 females) and without a history of back pain participated in this study. OUTCOME MEASURES: A combination of magnetic resonance imaging and computed tomog-raphy scans of the lumbar spine of all subjects were taken at baseline, 60d, 90d, and 7d post-BR. Back pain was self-reported. METHODS: IVD morphology, spine length, and back pain were compared between CTR and LMMS subjects. RESULTS: Compared with untreated CTRs, LMMS attenuated mean IVD swelling by 41% (p !.05) at 60d and 30% (p !.05) at 90d. After 7 days of reambulation, disc volume of the CTR group was still 8% (p!.01) greater than at baseline, whereas that for the LMMS group returned the disc volume to baseline levels. In contrast to BR alone, LMMS also retained disc convexity at all time points and red