Cerebral phaeohyphomycosis—a cure at what lengths.pdfVIP

376 /infection Vol 9 June 2009 Review Cerebral phaeohyphomycosis—a cure at what lengths? Dong Ming Li, G Sybren de Hoog Cerebral phaeohyphomycosis is a fungal infection of the brain typically caused by Cladophialophora bantiana, Exophiala dermatitidis, and Rhinocladiella mackenziei, all of which belong to the order Chaetothyriales. The disease results in black, necrotic brain tissue, black pus, and black cerebrospinal fl uid. Pathogens usually reach the brain through the bloodstream or lymphatic fl uid and occasionally through direct spreading or accidental inoculation. Patients can pr