Differential regulation of the Sir2 histone.pdfVIP

Research Article Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases S. Kyrylenko a, O. Kyrylenko a, T. Suuronen a and A. Salminen b,* a Department of Neuroscience and Neurology, University of Kuopio, P.O. Box 1627, 70211 Kuopio (Finland) b Department of Neurology, University Hospital of Kuopio, P.O. Box 1777, 70211 Kuopio (Finland), e-mail: antero.salminen@uku.fi Received 28 February 2003; received after revision 19 June 2003; accepted 24 June 2003 Abstract. The Sir2 histone deacetylase gene family con- sists of seven mamma