- 1、本文档共5页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
GIST 间质瘤定义
Gastrointestinal stromal tumor 1
Gastrointestinal stromal tumor
Gastrointestinal stromal tumor
Classification and external resources
Histopathologic image of gastrointestinal stromal tumor of the stomach. Hematoxylin-eosin stain.
DiseasesDB 33849 [1]
MeSH D046152 [2]
Endoscopic image of GIST in fundus of stomach, seen
on retroflexion.
Same GIST seen on forward view of the endoscope
showing overlying clot.
A gastrointestinal stromal tumor (GIST) is one of the most
common mesenchymal tumors of the gastrointestinal tract (1-3%
of all gastrointestinal malignancies). They are typically defined as
tumors whose behavior is driven by mutations in the Kit gene or
PDGFRA gene, and may or may not stain positively for Kit.[3]
Signs and symptoms
Patients present with trouble swallowing, gastrointestinal
hemorrhage or metastases (mainly in the liver). Intestinal
obstruction is rare, due to the tumors outward pattern of growth.
Often, there is a history of vague abdominal pain or discomfort,
and the tumor has become rather large by time the diagnosis is
made.
Generally, the definitive diagnosis is made with a biopsy, which
can be obtained endoscopically, percutaneously with CT or
ultrasound guidance or at the time of surgery.
Diagnosis
As part of the analysis, blood tests and CT scanning are often
undertaken (see the radiology section).
A biopsy sample will be investigated under the microscope. The
histopathologist identifies the characteristics of GISTs (spindle
Gastrointestinal stromal tumor 2
cells in 70-80%, epitheloid aspect in 20-30%). Smaller tumors can usually be found to the muscularis propria layer
of the intestinal wall. Large ones grow, mainly outward, from the bowel wall until the point where they outstrip their
blood supply and necrose (die) on the inside, forming a cavity that may eventually come to communicate with the
bowel lumen.
When GIST is suspected—as opposed to other causes for similar tumors—the pathologist can use
immunohistochemistry (specific antibodies
您可能关注的文档
- F1-4.20-27.pdf
- FAAC道闸中文资料.pdf
- Fabrication and performance of anode-supported solid oxide fuel cells via slurry spin coating.pdf
- F9-chapter 19.pdf
- Factor pricing models.ppt
- Factors affecting fat droplet aggregation in whipped frozen.pdf
- Factors affecting selective rejection of proteins within a binary mixture during cross-flow ultrafil.pdf
- F5-China-Agilit-2015-Security.pdf
- Factors controlling Zostera marina L. growth in the eastern and western Pacific Ocean Comparisons be.pdf
- Fade To Black—吉他谱.pdf
文档评论(0)