两种大环内酯类抗生素治疗小儿支原体肺炎的成本-效果分析.pdfVIP

朱玫 , 等 : 两种大环内酯类抗生素治疗小儿支原体肺炎的成本 - 效果分析 • 67 • 两种大环内酯类抗生素治疗小儿支原体肺炎的成本 -效果分析 朱玫，吴惠兰 （1. 浙江省临海市妇幼保健院，浙江 临海 317000；2. 浙江台州医院，浙江 台州 317000） 【摘要】 目的：评价两种大环内酯类抗生素治疗小儿支原体肺炎（MMP）的疗效及成本。方法：选择浙江省临海 市妇幼保健院小儿科 MMP 患儿 120 例，随机分为 3 组，采用不同方式治疗，A 组为阿奇霉素静滴组，B 组为红霉素 静滴组，C 组为红霉素 - 阿奇霉素序贯疗法。对 3 组疗效及成本 - 效果进行分析评价。结果：3 组总有效率比较，C 组 与 A 组、B 组差异无统计学意义（P 0.05）；成本 - 效果比（C/E）及增量成本 - 效果比（△ C/ △ E），C 组最低。 药价下降 10%，3 组成本 - 效果比（C/E）及增量成本 - 效果比（△ C/ △ E），C 组仍是最低。治疗过程中，A、B 组 出现不良反应，经对症处理后不良反应消失；C 组无明显不良反应发生。3 组不良反应发生率比较，差异有统计学意 义（P 0.05）。结论：遵循安全、有效、经济的用药原则 , 红霉素 - 阿奇霉素序贯疗法最佳。 【关键词】 支原体肺炎；阿奇霉素；红霉素；成本 - 效果分析 【中图分类号】 R969.3 【文献标志码】 A 【文章编号】 1672-3384(2016)03-0067-03 doi:10.3969/j.issn.1672-3384.2016.03.017 Cost-effective analysis of two different kinds of common macrolide antibiotics for the treatment of children with mycoplasma pneumonia ZHU Mei, WU Hui-lan （1. Linhai City, Zhejiang Province, Zhejiang Linhai 317000, China; 2. Taizhou Hospital zhejiang Province, Tanzhou 317000, China） 【Abstract】 Objective: To evaluate the curative efficacy and cost-effectiveness of two different kinds of macrolide antibiotics in the treatment of children with mycoplasma pneumonia (MPP). Methods: A total of 120 patients with MPP in the Department of pediatrics of our hospital were randomly divided into Group A, B and C. Patients in Group A, B and C were treated with azithromycin, erythromycin and erythromycin and azithromycin sequential therapy respectively. The curative efficacy and cost-effectiveness of three groups were assessed. Results: The total effective ratio of three groups showed no significant difference (P 0.05). Among cost-effective ratio and incremental cost-effective ratio of three groups, Group C was the lowest. When drug prices fell by 10%, cost-effectiveness ratio and the incremental cost-effectiveness ratio of three groups, Group C continued to be the lowest. There were cases with adverse reaction during treatment in Group A a