2013122710 何超 新制剂开发与应用论文.docx

2013级 制 药 工 程 学 院 新制剂开发与应用 课 程 论 文 英文题目Application of solid dispersion technology in traditional Chinese medicine preparation中文题目固体分散技术在中药制剂中的应用学 号2013122710姓 名何超专 业制药工程（民族制药）班 级民药131分 数指导教师覃引评 语2016年 5 月 日 固体分散技术在中药制剂中的应用 何超 （制药工程学院 制药工程民族制药方向） 摘要：固体分散技术系将难溶性药物以分子、胶态、微晶或无定型状态高度分散于水溶性、难溶性或肠溶性固体载体中形成固体分散体（solid dispersion SD）的药物制剂技术。该技术始于1961年Sekiguchi[1]制备磺胺噻唑-尿素固体分散物，在中药药剂上的应用始于1970年芸香油滴丸的上市。药物，特别是难溶性固体药物，在制剂中的分散状态是影响其溶出与吸收的重要因素，固体分散体能够将药物高度分散，若载体为水溶性材料，则可大大改善药物的溶出与吸收，从而提高其生物利用度，成为制备高效、速效制剂的新技术；若采用难溶性或肠溶性载体材料将药物制成固体分散体，可使药物具有缓（控）释和定位释药的特征。随着高科技和高分子材料的发展，固体分散技术将在中药制剂的剂型和工艺改进中发挥更重要的作用。 关键词：固体分散技术；中药制剂；难溶性；固体药物 Application of solid dispersion technology in traditional Chinese medicine preparation He Chao (Instituteof?pharmaceutical?engineering?national?pharmaceutical?professional) Abstract：Solid dispersion technology, poorly soluble drugs to molecules, colloid, microcrystalline or no amorphous state highly dispersed in water soluble and inso-luble or enteric coated solid support forms a solid dispersion (solid dispersion (SD) pharmaceutical technology. This technology since 1961 Sekiguchi of preparing su-lfathiazole urea solid dispersion and application in traditional Chinese medicine began in 1970 rue oil dripping pills listed. Drugs, especially the insoluble solid drug, in the formulation of decentralized state is an important factor to affect the digestion and ab-sorption of the solid dispersion can be highly dispersed drug, if the carrier is a water soluble materials, can greatly improve the drug dissolution and absorption, so as to i-mprove its bioavailability and become efficient preparation, fast effective preparat-ion and new technology; if the insoluble material of carrier or enteric coated medicine can be prepared into solid dispersion, so that the drug has characteristics of slow / contro-lled release and targeted drug delivery. With the development of high technology and polymer materials, soli