TableS2.Initialconditionsofthecomputationalmodel.docVIP

Table S2. Initial conditions of the computational model. Species name Initial Amount (nM) Additional descriptionAKT444Serine, threonine protein kinase (also known as protein kinase B)ASK1200Apoptosis signal-regulating kinase 1 (also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5))EGF5Epidermal Growth FactorEGFR300 HYPERLINK /wiki/Epidermal_growth_factor_receptor \o Epidermal growth factor receptor Epidermal growth factor receptorERK750 HYPERLINK /wiki/Extracellular_signal-regulated_kinases \o Extracellular signal-regulated kinases Extracellular signal-regulated kinases 1/2Gab143.1Grb2-associated-binding protein 1Grb282.4Growth factor receptor binding protein 2MEK772MAP ERK kinase 1/2 (also known as MAPKK-1/2, MAP2K1/2) MKK772Mitogen-activated protein kinase kinase?3/6 (MKK3/6)MKKpase200Specific phosphatase of MKK3/6P38750P38 mitogen-activated protein kinase α (p38-α), also called Mitogen-activated protein kinase 14P38pase35Specific phosphatase of P38-αPase160Specific phosphatase of RafPase2200Specific phosphatase of MEKPase335Specific phosphatase of ERKPDK1500Phosphoinositide-dependent protein kinase 1PI3K240Phosphatidylinositol 3-kinasePIP2200Phosphatidylinositol bisphosphatePP2A50Protein phosphatase 2A (AKT phosphatase)proNOX200 HYPERLINK /wiki/NADPH \o NADPH Nicotinamide adenine dinucleotide phosphate-oxidase?(NADPH?oxidase) without active Rac GTPasePTEN693Phosphatase and tensin homolog RacGDP95.7Ras-related C3 botulinum toxin substrate GTPase binding with Guanosine diphosphate (GDP)Raf743RAF proto-oncogene serine/threonine-protein kinase RasGAP93.6 HYPERLINK /wiki/GTPase-activator_protein_for_Ras-like_GTPase \o GTPase-activator protein for Ras-like GTPase Activator protein for?Ras-like GTPaseRasGDP95.7Rat sarcoma protein binding with Guanosine diphosphate (GDP)RTKpase450Receptor tyrosine kinase phosphatase (EGFR phosphatase)