脑卒中-并发症论文电针百会风池干预脑卒中后认知功能障碍的临床研究.docVIP

脑卒中/并发症论文：电针百会、风池干预脑卒中后认知功能障碍的临床研究 【中文摘要】通过电针治疗脑卒中后认知功能障碍患者,观察电针百会、风池穴治疗脑卒中后认知功能障碍的疗效。方法：采用非盲法随机对照试验设计方案,将42例符合纳入标准的脑卒中后认知功能障碍患者随机分为治疗组和对照组。每组各21例,两组患者均给予神经内科一般常规治疗和康复训练。治疗组在此基础上,加用电针百会、风池；对照组不加其他干预措施。在治疗前后采用简易精神状态检查法评分表MMSE、事件相关电位P300相关指标(潜伏期、波幅)测定对认知功能进行评定。结果：(1)MMSE评分量表经统计学分析可以看出,治疗组认知功能有所改善,与治疗前相比,差异有统计学意义(p0.05)。(2)治疗组MMSE评分,在定向力、计算力、记忆力、三步指令统计学上有显著差异(P0.01),而对照组MMSE评分总体差异虽然无统计学意义,但在定向力、计算力差异有统计学意义(p0.05)。(3)事件相关电位P300指标潜伏期、波幅经统计学分析,治疗组治疗前后有显著差异(p0.01)；对照组潜伏期治疗前后有差异有显著意义(p0.01),波幅治疗前后差异有统计学意义(p0.05)。(4)治疗后治疗组MMSE评分、事件相关电位P300指标潜伏期、波幅的改善情况与对照组相比差异有统计学意义(p0.01),治疗组的疗效优于对照组。(5)事件相关电位ERP-P300潜伏期与MMSE评分呈负相关,且差异有统计学意义(P0.01),事件相关电位ERP-P300波幅与MMSE评分呈正相关,且差异有统计学意义(P0.01)。结论：(1)电针百会、风池穴及对照组都能改善脑卒中后认知功能障碍的认知功能,但电针组的疗效优于对照组,两组治疗效果差异有统计学意义。(2)事件相关电位ERP-P300潜伏期与MMSE评分呈负相关,事件相关电位ERP-P300波幅与MMSE评分呈正相关,验证了事件相关电位P300可作为认知障碍评价的客观指标,对评估脑卒中后认知功能障碍严重程度有重要意义。(3)采用事件相关电位P300评估认知功能,应用电针治疗脑卒中后认知功能障碍可作为一种较为科学、可行的评估治疗组合在今后的临床中广泛应用。 【英文摘要】:The objective of this study was to investigate the clinical effect of the treatment of Electroacupuncture given at DU20 and GB20 for the patients who have had cognitive impairment after stroke,and then to find a more feasible and effective treatment for cognitively impaired patients.Methods:This clinical trial employed a randomized-controlled and non-blinded design.42 patients were randomly assigned to two groups, treatment group and control group,21 patients in each group. The two groups of patients were given both conventional neurological treatment and rehabilitation training. On this basis, the treatment group was treated again by using the treatment of Electroacupuncture given at DU20 and GB20; No more treatment was added to the treatment in control group. Before and after treatment, the Mini Mental State Examination score sheet MMSE and P300 (latency and amplitude) of event-related potential were used to measure the cognitive functions.Results:(1)MMSE rating scale by statistical analys