甲状腺和抗甲状腺素药.pptVIP

甲状腺激素和抗甲状腺药; The two major thyroid hormones are thriiodothyronine(T3) and thyroxine(T4).They are essential for normal growth and development and play an important role in energy metabolism. The predominant actions of thyroid hormones are mediated by binding to nuclear thyroid hormone receptors and modulating transcription of specific genes. Antithyroid drugs consist of thioureas, iodide, radioiodine (131I) and β-adrenoceptor antagonist. Thioureas inhibit the synthesis of thyroid hormones. Propythiouracil can also block the conversion of T4 to T3 in peripheral tissues.;High concentrations of iodide appear to influence almost all important aspects of iodide metabolism by the thyroid gland,especially including an inhibition of the release of thyroid hormones. 131I exerts a destruction of thyroid gland by beta particles. The major indications for the therapeutic use of thyroid hormones are for hormone replacement therapy in patients with hypothyroidism or cretinism,and antithyroid drugs are for the treatment of hyperthyroid individual.;学习目的与要求;;;甲状腺激素—生物合成、分泌;甲状腺激素：;anterior pituitary;;;;;;;硫脲类—【作用机制】 ;;;;硫脲类—不良反应 ;;;;;;;