卒中可塑性的CST量化研究2008Structural damage to the corticospinal tract correlates with bilateral se.pdf

/locate/ynimg NeuroImage 39 (2008) 1370–1382 Structural damage to the corticospinal tract correlates with bilateral sensorimotor cortex reorganization in stroke patients ? Judith D. Schaechter, Katherine L. Perdue, and Ruopeng Wang MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA Department of Radiology, Harvard Medical School, Boston, MA, USA Received 29 June 2007; revised 26 September 2007; accepted 28 September 2007 Available online 16 October 2007 Damage to the corticospinal tract (CST) in stroke patients has been Gerloff et al., 2006; Jaillard et al., 2005; Lotze et al., 2006; associated with functional reorganization in the ipsilesional and Loubinoux et al., 2003; Nudo and Milliken, 1996; Tombari et al., contralesional sensorimotor cortices. However, it is unknown whether 2004; Weiller et al., 1993). Animal studies have shown that the a quantitative relationship exists between the extent of structural extent of focal damage to the M1 results in a proportionate level of damage to the CST and functional reorganization in stroke patients. functional reorganization in remote cortices (Biernaskie et al., The purpose of the current study was to examine the relationship 2005; Dancause et al., 2006; Frost et al., 2003). A few animal and between structural CST damage and motor task-related cortical activity in chronic hemiparetic stroke patients. In 10 chronic patient studies have explicitly demonstrated that functional hemiparetic stroke patients with heterogeneous lesions, CST damage reorganization in remote sensorimotor cortices after focal damage was quantified using conventional structural magnetic resonance to the M1 or CST is involved in compensati