3-肿瘤与免疫-抗肿瘤机制.pptxVIP

抗肿瘤免疫机制Mechanism of Immune Response to Tumor;Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy. NATURE REVIEWS | CANCER VOLUME 14 | FEBRUARY 2014 ;细胞免疫抗肿瘤作用;;T细胞在抗肿瘤的特异性免疫中是主要效应细胞。;1. T细胞的分化、成熟和活化 2. T细胞抗肿瘤的效应机制;T细胞的分化、成熟和活化 T细胞在胸腺中分化、成熟 T细胞抗原受体和相关分子 抗原的识别和T细胞活化、增殖;Most of the immature thymocytes in the thymus die either because they make an unproductive TCR-gene rearrangement or because they fail positive or negative selection. Three mature T-cell populations(green, pink, blue) are produced and move to the peripheral lymphoid organs. Most T cells express the ??