浅谈回顾性临床研究.pptVIP

难易与价值的权衡点 浅谈回顾性临床研究 ;回顾性病例对照研究;标题;前言;方法;研究设计;病例介绍;随访与数据收集;结果总结;讨论;讨论点;文献学习;Background: This study aimed to show whether circulating BMPs levels are associated with increased risk of mortality in PAH patients. Methods: A total of 156 PAH patients including 43 HPAH and 113 IPAH diagnosed by gene screening were enrolled in the study. Circulating BMPs were measured by ELISA in plasma samples from HPAH (n = 43), IPAH (n = 113) and controls (n = 51). Clinical characteristics at baseline and long-term survival were compared according to the different BMPs levels. Results: HPAH patients had significantly higher BMP7 concentrations than IPAH and controls (20.1 (9.4, 55.2) vs. 6.5 (3.5, 11.7) and 2.5 (0.9, 6.6) pg/ml, respectively; P 0.001). Elevated plasma BMP7 were associated with a higher risk of mortality after adjustment for sex, 6-minute walk distance, mean right atrial pressure, mean pulmonary arterial pressure, pulmonary vascular resistance, and cardiac output (HR = 1.904, 95% CI 1.021-3.551; P = 0.043). IPAH patients with a BMP7 level more than 7.85 pg/ml had a higher risk of mortality than those with a low BMP7 concentration (P = 0.042, log rank test). Conclusions: Levels of circulating BMP7 correlate with mortality in PAH, and may be a predictor of disease in HPAH and IPAH patients.;研究背景;研究背景;1,BMPR2 expression is reported to be greatly reduced in patients with heritable pulmonary arterial hypertension 2, BMP2, 4 and 7 have been shown to be the most important ligands for BMPR2 signaling in Pulmonary vessels ;Methods Study Design and Patient Population纳入排除标准 伦理问题：知情同意书，伦理协会批文 随访 Hemodynamic Measurements and 6-Minute Walk Distance (6MWD) Test Measurement of Plasma BMPs Concentrations Statistical Analysis