1 securinine analgesic effect of fentanyl and its mechanism.docVIP

 PAGE \* MERGEFORMAT 8 1 securinine analgesic effect of fentanyl and its mechanism Authors: Wang, the payment of the tsunami, Liu Huanhuan, Ni Weiwei, GUO Ji-dong, Wu Jing-Ru [Abstract] Objective To study the analgesic effect of fentanyl and the GABAA receptor, and to explore the possible mechanism of analgesic effect of fentanyl. Methods Kunming mice (female 36) according to completely randomized design divided into four groups (n = 9): saline group, a securinine group (10 mg / kg), fentanyl group (0.3 mg / kg), 1 securinine (10 mg / kg) fentanyl (0.3 mg / kg) group. Hot-plate test in mice were measured before and after treatment of the pain threshold. Results 1 securinine raise the pain threshold of fentanyl (P amp;lt;0.05). Conclusion analgesic effect of fentanyl with the GABAA receptor partial correlation. [Keywords:] fentanyl; a securinine; analgesic; hot-plate test For the opioid analgesics fentanyl, the analgesic effect of morphine is about 100 ~ 180 times, pethidine 550 ~ 1000-fold [1], and has low toxicity to the cycles of light, the limitation short (15 ~ 30 min), after breathing on his own quick recovery and so on. In recent years, with the broad popularity of postoperative analgesia, in order to achieve good perioperative analgesia and sedation effects, preoperative use of diazepam and other benzodiazepines hua Zhuo drugs as a sedative to fentanyl, etc. opioids for postoperative analgesia in patients with more and more. However, the clinical study found that in order to hua Zhuo benzodiazepine-type drugs for premedication of patients required postoperative analgesia morphine dose increased, suggesting that benzodiazepine-type drugs may be antagonistic hua Zhuo analgesic effect of morphine, and This combination therapy approach to question [2-3]. Later by Wang Bin et al [4] Further studies confirmed diazepam could antagonize the analgesic effect of fentanyl and to propose its mechanism may be related to emotional benzodiazepine hua Zhuo enhance