5 - HT and its receptor in the role of motion sickness.docVIP

 PAGE \* MERGEFORMAT 17 5 - HT and its receptor in the role of motion sickness Keywords: 5 - HT 5 - hydroxytryptamine (5-HT, serotonin) as a neurotransmitter and vasoactive substances, widely distributed in the central nervous system and surrounding tissue, in pain modulation, sensorimotor, cardiovascular function and breathing, sleep, appetite and many other play an important role. Currently on the 5-HT receptors concentrated in the field of mental illness, but in recent years, foreign study found that ,5-HT and its receptor in the occurrence of motion sickness and adaptation process also plays an important role to study the variation of and mechanisms to facilitate the adoption of motion sickness drugs and nutritional interventions to promote the rapid recovery of brain body fatigue. This will 5-HT and its receptor in the role of motion sickness to do a review. 1 5-HT and motion sickness 11 5-HT in vivo distribution and metabolism of 5-HT exist in the digestive tract of approximately 90% of the chromaffin cells, 8% is found in platelets, the central nervous system, the total content of only 1% to 2%. Brain 5-HT neurons concentrated in the lower brain stem near the midline raphe nuclei (raphe nuclei), issued through the raphe nuclei of fiber downlink control spinal cord, forebrain and brainstem uplink control vast areas, while also through the cerebrospinal fluid to reach a broad role in other brain regions. As the branched-chain amino acids and 5-HT precursor L-tryptophan in competitive inhibition, therefore, a large number of previous studies by the food supplement branched-chain amino acids and thus affect the body’s state of mental strength. Widely reported [1,2] that the brain 5-HT and its metabolite 5-HIAA (5 - HIAA) concentration increased in the long campaign, fatigue, reached the peak. To give specific 5-HT agonist or antagonist, may shorten the time were so exhaustive exercise or extended. Add sugar, allow plasma free tryptop