5fluorouracil folate-conjugated chitosan nanoparticles and in vitro properties of.docVIP

 PAGE \* MERGEFORMAT 8 5fluorouracil folate-conjugated chitosan nanoparticles and in vitro properties of [Abstract] Objective To study the folate-conjugated chitosan nanoparticles containing 5  FU in vitro methods and the nature of the preparation. Methods According to the coupling of folic acid and chitosan to choose the best process conditions than by folic acid and chitosan on the activity of amino-ester reaction of folate-conjugated chitosan prepared, and then prepared by ionic crosslinking folate-conjugated chitosan Sugar nanoparticles inclusion 5  fluorouracil, and thus made into drug-loaded nanoparticles. The results were prepared chitosan conjugates of folic acid, and inclusion 5  FU into the nanoparticles, the drug loading was 10.4%, the encapsulation efficiency was 50.5%, 8 h cumulative release reached 35.9%. Conclusion optimize the folate-conjugated 5  fluorouracil Preparation of chitosan nanoparticles. [Keywords:] folic acid; nanoparticles; 5  fluorouracil; chitosan Abstract: Objective To prepare folate  conjugated 5  fluorouracil  chitosan nanoparticles (5  FU  CSNP  folate) and evaluate its property in vitro. Methods The optimal technological conditions were selected according to the conjugated ratio of folate and chitosan. Folate  conjugated chitosan was prepared by the reaction of the activated folate ester with the amine group of chitosan. Folate  conjugated 5  fluorouracil  chitosan nanoparticles were then prepared with ionic cross  linking. Results Folate  conjugated 5  fluorouracil  loaded chitosan was prepared through different ways, and nanoparticles loading 5  FU was prepared. The encapsulation ratio of 5  FU  CSNP  folate was 50.5% and the drug loading was 10.4%. The total amount of accumulated release was 35.9% at the eighth hour. Conclusions The preparation condition of 5  FU  CSNP  folate was optimized. Keywords:: folate; nanoparticles; 5  fluorouracil; chitosan 5  fluoroura