A new generation of broad-spectrum fluoroquinolone antibiotic drug Factive.docVIP

 PAGE \* MERGEFORMAT 6 A new generation of broad-spectrum fluoroquinolone antibiotic drug Factive [Abstract] Gemifloxacin is a South Korean company LG Life Science developed fourth-generation fluoroquinolone antibacterial drugs, it also acts on bacterial DNA gyrase and DNA topoisomerase IV, increased antibacterial activity and lower resistance rates. Gemifloxacin In addition to Gram-negative bacteria to maintain a strong antimicrobial activity, the right, including multi-drug-resistant Streptococcus pneumoniae, including gram-positive bacteria also have good activity. Gemifloxacin has a good pharmacokinetic properties, the organization has strong penetration can be powerful to kill the site of infection pathogens. It is little interaction between the drug has good safety and tolerability, and is the clinical treatment of acute exacerbation of chronic bronchitis, community-acquired pneumonia and acute sinusitis a good drug. [Keywords:] Gemifloxacin; fluoroquinolone; antibacterial effect; pharmacokinetics; clinical efficacy ABSTRACT Gemifloxacin is a novel, broad  spectrum fluoroquinolone. This review summarized the mechanism of action, antibacterial activity, pharmacokinetic, pharmacokinetic / pharmacodynamic, adverse effect and therapeutic effect of gemifloxacin. KEY WORDS Gemifloxacin; Fluoroquinolone; Antibacterial activity; Pharmacokinetic; Therapeutic effect Gemifloxacin is a South Korean company LG Life Science developed fourth-generation fluoroquinolone antibacterial drugs [1], in April 2003 by the U.S. FDA clearance to market, in July 2006 to obtain market approval in China. Gemifloxacin is a fluoroquinolone in the C7 position was replaced by pyrrolidine derivatives, is a broad-spectrum quinolone antibacterial drugs, which in addition to maintaining against Gram-negative bacteria (including other antibiotic resistant) and excellent activity, the right, including multiple drug-resistant Streptococcus pneumoniae, including gram-positive bacteria als