ABCG2 gene single nucleotide polymorphism in progress.docVIP

 PAGE \* MERGEFORMAT 20 ABCG2 gene single nucleotide polymorphism in progress [Abstract] ABCG2 transporter is an ATP binding protein, in human normal and tumor tissues were expressed, can inhibit the gastrointestinal absorption of some exogenous substances, involved in forming the blood-brain, fetal blood barrier and other physiological functions. At the same time ABCG2 is also a new drug discharged from the pump, multidrug resistance is an important mechanism. ABCG2 gene single nucleotide polymorphisms (single nucleotide polymorphism, SNP) may affect the ABCG2 protein expression and function, and disease prone emotional and related pharmacokinetics. ABCG2 single nucleotide polymorphism as a new hotspot, this paper at home and abroad in recent years, research on the ABCG2 gene SNP reviewed. [Keywords:] ABCG2 gene; single nucleotide polymorphisms AbstractABCG2 protein is one of the ATP-binding transporters expressed in human normal cells and tumor tissues, ABCG2 can inhibit the gastrointestinal absorption of which can be exogenous substances, involved in many physiological functions such as the formation of the blood-brain and placental-blood barrier. ABCG2 is a new drug efflux pump as well. It is one cause of multidrug resistance. ABCG2 gene single nucleotide polymorphism may affect the expression and function of ABCG2 protein. ABCG2 gene SNP is associated with disease susceptibility and pharmacokinetics. Single nucleotide polymorphism of ABCG2 is becoming a new hotspot. Domestic and international research on the ABCG2 gene SNP is reviewed in this paper. Keywords:: ABCG2 gene; single nucleotide polymorphism 1998, Doyle et al [1] first detected in breast cancer cell lines MCF-7/AdrVp to a transmembrane transporter protein, called breast cancer resistance protein (breast cancer resistance protein, BCRP), phylogenetic analysis of the gene for the ABC transporter superfamily (ATP-binding cassette transporter superfamily, ABC transporter superfamily)