About puerarin on cerebral ischemia behavior and protective effect of pathological changes.docVIP

 PAGE \* MERGEFORMAT 7 About puerarin on cerebral ischemia behavior and protective effect of pathological changes [Abstract] Objective: To study the puerarin on cerebral ischemia-reperfusion injury, and to explore the mechanism of its neuroprotective effects. Methods: Wistar rats were divided into 3 groups: sham operation group, model group and treatment group, the use of focal cerebral ischemia reperfusion model (ie, middle cerebral artery occlusion), pretreatment with puerarin, and then were observed and the detection of brain morphology, brain water content and disease score index. Results : Compared with model group, treatment group, the pathological brain tissue damage and edema significantly reduced infarct size reduction in disease score was significantly reduced. Conclusion: Effects of puerarin on cerebral ischemia has a protective effect. [Keywords:] puerarin; focal cerebral ischemia; brain water content; disease score Department of legume Pueraria lobata root, according to historical records, it has the function of expelling wind and relieving, treating diabetes, stroke, headache and back pain embolism items [1]. Puerarin (Puerarin, Pue) is from Gegen isoflavone extract a single chemical called 4,7-dihydroxy-8 D glucosyl isoflavones [2]. Modern pharmacology studies have shown that it has the role of β receptor blockers [3] and increase cerebral blood flow and cerebral metabolism [1]. Experimental results show that myocardial ischemia and its acute cerebral ischemia have a certain protection [4]. then for focal cerebral ischemia and reperfusion injury, whether puerarin has a protective effect? #8203;#8203;This study conducted the following experiments this study. 1 Materials and methods 1.1 Animals and Grouping Healthy male Wistar rats weighing 250 ~ 280g, Huazhong University of Science Experimental Animal Center of Tongji Medical College. Experiment, Wistar rats were randomly divided into 3 groups: sham operation group (Sham), isch