ABPS derivatives in diabetic rat islet cell morphology and renal function.docVIP

 PAGE \* MERGEFORMAT 13 ABPS derivatives in diabetic rat islet cell morphology and renal function Of: Jin Liqin, Xuesheng Xia, CHEN Xiu-fang, QIAN Song [Abstract] Objective?: To investigate the ABPS (AbP) and its sulfate and phosphate derivatives of diabetes (DM) rat islet cell morphology and renal function. Methods: Streptozotocin induced SD rats To DM model was AbP, bidentata polysaccharide sulfate derivatives (S-AbP) and ABPS phosphate derivatives (P-AbP) on the DM blood glucose, islet cell morphology and secretion; serum creatinine (Scr ) and blood urea nitrogen (BUN) levels were observed on renal function in DM. Results: AbP its two derivatives can be significantly reduced blood glucose concentrations of DM (P? lt;0.05 or P? lt;0.01) , S-AbP and P-AbP can significantly reduce the DM rat pancreatic islet -cell damage, the insulin-positive cells increased; S-AbP significantly reduced Scr and BUN levels (all P? lt;0.01), P-AbP and AbP significantly lower Scr levels (all P? lt;0.01). Conclusion: S-AbP and P-AbP of high blood glucose islet cell injury induced significant role in the protection and restoration of renal function with different degrees of improvement. [Keywords:] bidentata; polysaccharide; derivatives; diabetes mellitus; islet cells; renal function; rat Abstract:? Objective: To study the effects of Achyranthes bidentata polysaccharides (AbP) and the sulfated derivative (S-AbP) and the phosphorylated derivative? (P-AbP)? Of AbP on the morphology of islet cells and renal function in diabetic rats . Methods:? Diabetes was induced by a single injection of streptozotocin, changes of fasting blood glucose and morphology and secretion of islet cells in diabetic rats treated respectively with S-AbP, P-AbP and AbP were observed, the renal function was also evaluated by examining serum creatinine (Scr) and blood urea nitrogen (BUN). Results:? Compared with diabetes group, the blood glucose significantly decreased in S-AbP, P-AbP and AbP treated