Acetylcholine receptor α subunit peptide 97-116 produced experimental model of myasthenia gravis.docVIP
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Acetylcholine receptor α subunit peptide 97-116 produced experimental model of myasthenia gravis
PAGE \* MERGEFORMAT 21
Acetylcholine receptor α subunit peptide 97-116 produced experimental model of myasthenia gravis
Of: Huren Fei, Song Yafang *, LIU You-Zhang, Li Lianglong, Xiao-Yan Huang, HYPER Gao, Ji love winter, Zhang Jiumei
[Abstract] Objective To study acetylcholine receptor @ subunit 97-116 peptide production of experimental myasthenia gravis (EAMG) in animal models. Approach to Lewis rat experimental murine subcutaneous injection of synthetic acetylcholine receptor @ subunit 97-116 peptide were observed in rats after inoculation of the General Conditions and weight, Lennon score changes, the application detecting low frequency repetitive electrical stimulation attenuated response compared with control rats. The results of model group rats after the 1st immunization gradually MG symptoms occur, slow or decreased weight gain, even weight loss, hair becomes dull, rough or even fall off again after the booster immunization significantly increased the symptoms. Lennon clinical score of 29 or more scores in a parallel RNS test, 36 model mice 32 5 Hz repetitive stimulation power decay rategt; 10%, while the decay rate of the control group lt;10%, the difference was statistically significant (P lt;0.01). Conclusion murine subcutaneous injection of acetylcholine receptor @ subunit 97-116 peptide can be successfully produced experimental rat model of autoimmune myasthenia gravis.
[Keywords:] myasthenia gravis; acetylcholine receptor; @ subunit; peptide
Myasthenia Gravis (Myasthenia gravis, MG) is the acetylcholine receptor antibody (AchR-Ab)-mediated cellular immunity and complement dependent participation of an autoimmune disease, lesions mainly involving the neuromuscular junction at the postsynaptic membrane acetylcholine receptors, resulting in transmission at the neuromuscular junction dysfunction.
Officials from the electric eel electric use to extract the active immunization with AchR as susceptible mice immunized to establish EAMG mo
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