Acidic drugs in microemulsion liquid chromatography retention behavior.docVIP

 PAGE \* MERGEFORMAT 22 Acidic drugs in microemulsion liquid chromatography retention behavior [Abstract] acidic drug naproxen, ibuprofen, diclofenac, phenylalanine and 2,4 - dichlorophenoxyacetic acid as the research object of the acidic drugs in microemulsion liquid chromatography retention mechanism, the establishment of acidic drugs the capacity factor (k ‘) and surfactant concentration, cosurfactant concentrations, lipophilic organic solvent concentration and mobile phase pH, the correlation between the models. The results show that the surfactant, cosurfactant and the pro- lipid concentration of organic solvent and mobile phase pH values #8203;#8203;on the acid capacity factor of the drug entirely consistent with the theoretical model. the establishment of the retention model can reflect the microemulsion liquid chromatography in the microemulsion composition and pH values on the retention behavior of acidic drugs. [Keywords:] microemulsion liquid chromatography, retention model, retention behavior, naproxen, ibuprofen, diclofenac, phenylalanine, 2,4 - dichlorophenoxyacetic acid Abstract The retention mechanism of acid drugs such as naproxen, ibuprofen, diclofenac, phenylalanine and 2,4-dichlorophenoxy acetic acid in microemulsion liquid chromatography has been discussed.The retention modeling between capacity factors (k ‘) of acid drugs in microemulsion liquid chromatography and concentration of surfactant, cosurfactant and lipophilic organic solvent and pH value was set.The results showed the effect of change of concentration of surfactant, cosurfactant and lipophilic organic solvent and pH value on capacity factors of acid drugs in microemulsion liquid chromatography was fully consistent with the theoretical modeling.The retention modeling can better reflect the effect of composition of microemulsion solution and pH value on retention behavior of acid drugs in microemulsion liquid chromatography. Keywords Microemulsion liquid chromatography