Aconitine ginsenoside Rg1 and Tetrahydropalmatine transdermal penetration studies and collaborative.docVIP

 PAGE \* MERGEFORMAT 22 Aconitine ginsenoside Rg1 and Tetrahydropalmatine transdermal penetration studies and collaborative Of: Zhang Qing, Sun Yuming, Wang Qing, Hao Jiajia, Lizi Jing, Li Minghui [Abstract] Objective aconitine, ginsenoside Rg1 and transdermal absorption of Tetrahydropalmatine and their mutual influence between the percutaneous penetration. Methods Permcell KH-5P-type horizontal diffusion cell to separate the whole skin and stratum corneum skin in vitro transdermal experiments, using high performance liquid chromatography aconitine, ginsenoside Rg1 and Tetrahydropalmatine by the amount of accumulated, and calculate their percutaneous penetration kinetic parameters. Determination of the active ingredient of the oil-water partition coefficient (LogP ), study 2 and 3 combinations of active ingredients and mutual penetration behavior. The results of aconitine, ginsenoside Rg1 and Tetrahydropalmatine in the diffusion coefficient of the whole skin were 123.95,50.32,96.25 (× 10-10 cm2 / s), the activity of the diffusion coefficient of the epidermis were 539.00,93.60,354.70 (× 10-10 cm2 / s), LogP followed 1.66,0.66,0.57 respectively. In three kinds of effective components of the system of coexistence, the three The cumulative volume of those 64% through 293% improved to varying degrees. Conclusions combination of active ingredients 3 percutaneous absorption will produce synergistic effects, which aconitine and ginsenosides Rg1 synergy between the penetration through the skin the most significant effect . [Keywords:] aconitine, ginsenoside Rg1, tetrahydropalmatine, oil-water partition coefficients and permeation Abstract: Objective To study percutaneous absorption kinetics and synergistic penetration enhancement of tetrahydropalmatine, aconitine and ginsenoside Rg1. Methods The in vitro intact and stripped skin permeation experiments were carried out by using Permcell KH-5P horizontal proliferation system. The percutaneous kinetic parameter