Activin effect on Progress in nerve injury.docVIP

 PAGE \* MERGEFORMAT 11 Activin effect on Progress in nerve injury Keywords: activin; neurons Activin (activin) started as a factor in the regulation of anterior pituitary were isolated and purified in 1986, and can stimulate the follicle stimulating hormone (FSH) secretion. Activin belongs to transforming growth factor (TGF ) superfamily of multifunctional growth and differentiation factors, widely distributed in the early embryo formation, nerve cell differentiation and development, hematopoietic cell proliferation and differentiation, apoptosis and cancer formation, sex hormones has played an important role in regulating 1. New research reveals that activin as a neurotrophic and neuroprotective factor has to maintain neuronal survival and protect neurons from neurotoxic injury. Activin through further study the role of neurons in the body will reveal the significance of life processes for treatment of activin neuronal damage and degenerative diseases provides a new basis. 1 Structure and classification of activin Activin is composed of two subunits connected by disulfide bonds formed in the double-stranded protein, the A, B subunits of two of the three forms of activin, ie activin homodimer consisting of A (AA ), activin B (BB), as well as by the heterodimer A, B composed of activin AB. In recent years, have found that C, D, E and other sub-units, are located in different chromosomes, with independent coding mode 2. Activin (ActR) receptors are serine / threonine kinases (Ser / Thr) receptor, is divided into ActRI and ActRII 3, receptors are divided into A, B two subtypes (ActR A and ActR B ), by the respective gene encoding. ActR expression in many tissues, but the ActRIIAN ActRIIA mutants, mainly expressed in brain tissue. New research reveals, ActR interacting protein (ARIP), with the role of specific binding ActRII, thereby regulating cell signaling processes within the active factor 4. 2 activin biological effects of nerve i