Acute coronary syndrome serum MMP-2 MMP-9 and hs-CRP levels and its clinical significance.docVIP

 PAGE \* MERGEFORMAT 11 Acute coronary syndrome serum MMP-2 MMP-9 and hs-CRP levels and its clinical significance Of: Hukai Yu, Caixue Li, ZHANG Huai-qin, namely, light, Wang Zhongyong [Abstract] Objective: To observe the acute coronary syndrome in peripheral venous serum matrix metalloproteinase -2 (MMP-2, matrix metalloproteinase -9 (MMP-9, high sensitive C-reactive protein (hs-CRP levels and evaluate its clinical significance . Methods: 53 patients with acute coronary syndrome group for the ACS, acute myocardial infarction (AMI28 cases of unstable angina (UA25 cases. by enzyme-linked immunosorbent assay (ELISA serum levels of MMP-2, MMP- 9 levels, with immune nephelometry of serum hs-CRP. Replacement of stable angina (SA28 cases, the normal control group of 30 cases as the control. Results: ACS serum MMP-2, MMP-9, hs- CRP levels higher than the SA group (P lt;0.05 and control group (P lt;0.01.AMI serum levels of MMP-2, MMP-9, hs-CRP levels were significantly higher than that of UA group (P lt;0.05.ACS levels of serum MMP -9 and hs-CRP levels were positively correlated, MMP-2 and hs-CRP was no significant correlation. AMI levels of serum hs-CRP and cTnI level was positively correlated (r = 0.401, P lt;0.05. Conclusion: MMP-2, MMP -9 in the expression of ACS and the occurrence of acute coronary syndrome may be as a predictor of atherosclerotic plaque instability or rupture of the serum markers, the level of benefit in patients with coronary heart disease risk stratification. combined detection MMP-2, MMP-9 and hs-CRP may be an effective judge plaque stability, prediction of acute cardiovascular events in clinical indicators. [Keywords:] coronary syndrome matrix metalloproteinase MMP -9 -2 sensitivity C-reactive protein Acute coronary syndrome (ACS with unstable angina is based on (UA and acute myocardial infarction (AMI as a serious clinical manifestations of coronary heart disease type. Recent studies show that the occurrence of inflammation in AC