Aging cerebral ischemia and the relationship between white matter lesions.docVIP

 PAGE \* MERGEFORMAT 15 Aging cerebral ischemia and the relationship between white matter lesions Keywords: white matter; aging; cerebral ischemia Hemispheric white matter volume accounts for almost half of adults, mainly from the connection function, and many axons connected to the cerebral cortex gray matter, the cortex, subcortical gray matter connected to form a complete functional system. Damage to white matter lesions of its connectivity, resulting in interrupted contact of the functional areas, resulting neurobehavioral dysfunction. From the anatomical characteristics of a periventricular white matter, especially the deep white matter artery mainly through blood, little or no collateral circulation, while the gray matter has a rich collateral arterial circulation in the cerebral wall from the range of 3 ~ 10 cm within the terminal area as the watershed area, determine the characteristics of this anatomical area of white matter are vulnerable to the effects of ischemia and eventually lead to hypoxic ischemic demyelination. Affected by factors such as age hyaline degeneration of these small arteries, twisted extension, resulting in more blood flow kinetic energy loss. The anatomical characteristics of the decision when the blood flow decreases, the first bring disaster to the deep white matter 1. 1 large white matter lesions (WML) Refers to the distribution in the cerebral cortex white matter, periventricular and semi-oval centers scattered or diffuse lesions, the edge often irregular, CT appears as low density, the MRI T2 and FLAIR image showed: around the lateral ventricle before posterior horn of the cap-like abnormal high signal; strip or ring around the lateral ventricles of the abnormal high signal; deep white matter or basal ganglia area of abnormal high signal spots; patchy white matter in the abnormal high signal; diffuse changes: abnormal signal connection into the film, dispersed in the white matter area 2. WML includes: