Aging on the lumbosacral spinal cord nuclei 5urinary serotonin transporter expression.docVIP

 PAGE \* MERGEFORMAT 10 Aging on the lumbosacral spinal cord nuclei 5urinary serotonin transporter expression Study: Fan Ping Wang Lei Zhang Guoliang Shi Geming Lee Kum Kang Yunxiao [Abstract] Objective To observe the voiding of aging on the lumbosacral spinal cord nuclei 5-HT transporter expression. Methods 3 months old and 24 month old male Wistar rats was 6, was observed by immunohistochemistry lumbosacral spinal cord urination nuclei 5-HT transporter and its distribution strength of the immune response. pathologic sections to HPIAS 1000 color graphic analysis system after the old and gray matter of rats with combined (DGC, intermediolateral nucleus (IML, anterior horn nucleus (VH, dorsal lateral nucleus (DLN, spinal muscular bulbospongiosus nuclear (SNB and the sacral parasympathetic nucleus (SPNSERT gray value of the strength of the immune response. The results 3 months and 24 months lumbosacral spinal cord nuclei urination exist in SERT immunoreactive fibers and varicosities, observed in nuclei of the two groups was no distribution of SERT immunoreactivity changes in the way, but the performance of the different intensity of SERT immunoreactivity, 24-month group SERT immunoreactive fibers and varicosities less than 3 month group .24 month old rats, rats in the spinal cord DGC, IML, VH, DLN and SNB’s gray value intensity of SERT immunoreactivity was significantly higher than the 3 month group (P lt;0.05). Conclusions related to urinate lumbosacral spinal cord of aged rats nucleus weakened the strength of the immune response SERT suggest 5-HT nerve fibers of these nuclei is reduced with the Aging of domination. [Keywords:] 5-HT transporter, aging, urine, rat Studies have shown that many elderly people have voiding dysfunction, with age and frequent urination, urinary symptoms endless (1), old rats have similar voiding dysfunction (2), which may be related to bladder or urinary organs of the neural regulation of aging of change related. efferent