Alanine aminotransferase (ALT) elevation Analysis and clinical significance of blood donation screening.docVIP

 PAGE \* MERGEFORMAT 7 Alanine aminotransferase (ALT) elevation Analysis and clinical significance of blood donation screening Transaminase in the body’s metabolic process essential to the ‘catalyst’, mainly in the liver cells. Liver function checks the most basic, the most important indicator is the aminotransferase, usually including serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) 2. GPT found primarily in the soluble fraction of liver cells, puree, inflammatory lesions of liver cells, causing cell swelling, necrosis or liver cell membrane permeability, etc., may allow the release of alanine aminotransferase in the blood circulation, leaving serum alanine aminotransferase increased. AST mainly in the liver mitochondria, when the severe liver necrosis, or damage, can cause a significant increase in aspartate aminotransferase. Typically, the physical examination is the main check aminotransferase, alanine aminotransferase (ALT). 1% of liver cell injury, can make the blood a-fold increase in ALT concentration. Thus, ALT levels can be more sensitive to monitor the liver is damaged. However, higher transaminase is a very common situation, is not necessarily a problem with the liver. Because ALT is very sensitive to many factors can cause fluctuations in the normal transaminases, healthy people at different times within a day checking transaminase measurement results may be different. Transaminase levels between 0-40 is normal. If you exceed the normal range, the doctor will recommend further investigation once excluded because of laboratory equipment failures and operational errors caused by such factors as the possibility of errors. If aminotransferase levels are high, mostly by viral hepatitis or other liver disease caused by. But to determine if viral hepatitis and other tests needed to be done, combined with medical history, symptoms, and signs a comprehensive analysis. Even if recognized as viral hepatitis, it can not simply elevate