Aldosterone synthase gene polymorphism with essential hypertension in elderly.docVIP

 PAGE \* MERGEFORMAT 10 Aldosterone synthase gene polymorphism with essential hypertension in elderly Of: Hwei-Chen Su, Hu Xiaojun Chen Juan Li Feng Yan Kaili far more than James [Abstract] Objective To study the aldosterone synthase (CYP11B2 gene 344C / T polymorphism and essential hypertension (EH relevance. Methods for the elderly population-based case-control study EH, application technology on 289 cases PCR RELP the elderly in Chinese Han CYP11B2 gene 344C / T polymorphism. Results elderly population in Wuhan Han CYP11B2 gene 344C / T polymorphism to the major genotype TT and CT, C allele is less common. CYP11B2 gene 344C / T polymorphism was associated with the old EH (P lt;0.05). Conclusion The elderly population in Wuhan Han CYP11B2 gene 344C / T polymorphism is correlated with EH, carrying elderly hypertensive population compared with CC + CT genotype high. [Keywords:] Hypertension; aldosterone; gene; elderly Essential hypertension (EH is the most common cardiovascular diseases. As the renin-angiotensin-aldosterone system (RASS an important component of aldosterone in hypertension, the occurrence and development plays an important role. EH is a polygenic disease candidate gene approach is to study the pathogenesis of EH is one important way. This study explored the old Han Wuhan aldosterone synthase (CYP11B2 gene 344C / T polymorphism and its relationship with EH relations. 1 Subjects and methods 1.1 study August 2006 to November 2008 in our hospital and some inpatient physical examination. EH group inclusion criteria: meet the 1999 World Health Organization and the International Union of hypertension (WHO / ISH hypertension diagnostic criteria, Han nationality, aged 60 to 87 years old. Exclusion criteria: liver and kidney disease, cardiovascular disease (not including EH, .148 cases of secondary hypertension in patients with EH, 78 patients were male and female 70 cases. the control group: After examination (clinical examination,