Amyotrophic lateral sclerosis etiology.docVIP

 PAGE \* MERGEFORMAT 10 Amyotrophic lateral sclerosis etiology Keywords:: amyotrophic lateral sclerosis etiology Amyotrophic lateral sclerosis (ALS) is a progressive degenerative motor neuron disease, patients often die after 3 ~ 5 years (1,2). ALS most countries, the prevalence rate of 5 / 10 million to 7 / 10 million (3), high up to 40/10 million, Guam, the Pacific region’s high incidence of the disease, China is no more accurate statistics. Age of onset (adult type) 20 to 80-year-old, with an average 57-year-old male patient-fold in the female. According to Mulde, et al (4,5) statistics, about 5% ~ 10% of familial ALS, known as familial amyotrophic lateral sclerosis (FALS), Duocheng autosomal dominant inheritance, there was often a small part of the autosomal recessive. Sporadic and familial cases of similar clinical manifestations, but familial cases of early onset age of more than sporadic. In recent years, has been reported in childhood-onset persons, with an average age of onset is about eight years old the youngest who was only 9 months, childhood onset are mostly autosomal recessive inheritance, but its life span can be longer (6). The diagnosis of ALS and FALS is currently rely mainly on clinical presentation and family history (FALS), secondary inspection EMG is a more important indicator. Disease is currently no effective treatment. Cause of this disease has not yet been clear, put forth a range of possible causes of doctrine, involving viral infections, genetic factors, environmental factors and immune factors, but these theories are non-conclusive and can not very well explain the pathogenesis of this disease. Theory of a viral infection Long time ago that slow virus theory, but still no definite evidence of nervous system of ALS patients in the slow memory, the virus was almost abandoned in 1985 after the theory was proposed again. Polio virus on the motor neurons have special selective, it may prompt an atypical ALS may be caused by polio vi