Angelica SF topical treatment of osteoarthritis of the experimental study.docVIP

 PAGE \* MERGEFORMAT 15 Angelica SF topical treatment of osteoarthritis of the experimental study Study: New Liu Bao, Chen Liu Bin, Wang Hui, Qin Jun, commercial light [Abstract] [Objective] Angelica, intra-articular injection of sodium ferulate on rat osteoarthritis (OA) of the patients. [Method] 40 rats papain model established by OA knees, into the model after model the control group, 25% and 5% Angelica group, 0.5% and 0.1% sodium ferulate group, other 8 for normal control rats, each group corresponding concentration of intra-articular injection of drug or saline 0.1 ml, 3 日time, 6 weeks after the plasma, synovial fluid SOD, MDA, articular cartilage derived light microscopy to detect cartilage MMP-1, TIMP-1, Bcl-2, Bax expression. [results] 25% and 0.5% ferulic Angelica sodium can increase the plasma SOD activity in synovial fluid (all P lt;0.05) and reduced MDA levels (all P lt;0.01), decreased articular cartilage Mankin’s score (all P lt;0.01, reduced chondrocyte MMP-1, Bax expression ( P lt;0.05 or P lt;0.01), while the TIMP-1, Bcl-2 expression was increased (P lt;0.05 or P lt;0.01), 5% had no significant effect of angelica, 0.1% SF test indicators for some statistics significance. [Conclusion] Angelica, SF intra-articular injection treatment of rat OA are effective, and its role in a dose-dependent, ferulic acid is Angelica injection in treating OA of the effective monomer composition. [Keywords:] Osteoarthritis, angelica, SF, metalloproteinases, apoptosis Abstract: [Objective] To explore the therapeutic effects of angelica and sodium ferulate (SF) on experimental osteoarthritis and the related mechanisms in rats. [Method] Animal models of osteoarthritis were established in 40 rats by intra-articular injection of 4% papain. The rats were divided into five groups - model control group, 25% and 5% angelica treatment groups, 0.5% and 0.1% SF treatment groups.Another additional 8 rats were used as normal control. Bilateral knees of the animalsin