Angelica hormone on oxidative damage in patients with ulcerative colitis and arachidonic acid metabolism in.docVIP

 PAGE \* MERGEFORMAT 4 Angelica hormone on oxidative damage in patients with ulcerative colitis and arachidonic acid metabolism in [Abstract] Objective To investigate the Angelica Su (SF) for ulcerative colitis (UC) in patients with oxidative damage and arachidonic acid metabolism and its clinical significance. Detected 38 cases of ulcerative colitis patients and 30 healthy controls of blood MDA, LPO, SOD, NO, PGE2 and TXB2 levels of change, simultaneous detection of colonic myeloperoxidase (MPO) activity, evaluation of disease activity in patients with UC index (CAI) and endoscopic classification. Results UC patient group of blood MDA, LPO, NO, PGE2, TXB2 levels and colonic MPO activity was significantly higher than the normal control group, serum SOD activity was significantly lower than the normal control group (P amp;lt;0.01), SF after treatment were detected for UC patient group abnormal parameters significantly improved, while CAI score and endoscopic grading also significantly improved (P amp;lt;0.01). Conclusion angelicin UC patients significantly alleviated oxidative damage and inhibition of arachidonic acid metabolism of excessive inflammatory response and damage mitigation colitis, there is some clinical therapeutic value. [Keywords:] Angelica hormone; ulcerative colitis; oxidative damage; arachidonic acid metabolism Abstract: ObjectiveTo investigate the effects of Sodium Ferulate on the oxidative damage and arachidonic acid metabolism in patients with ulcerative colitis (UC) and its significance of clinic therapy. MethodsIn 38 patients with UC and 30 healthy people, prostaglandin E2 (PGE2), thromboxane B2 (TXB2), Malondiadchyde (MDA), Lipid superoxide (LPO), activity of superoxide dismutase (SOD) in blood and activity of myeloperoxidase (MPO) in colon were detected by corresponding kits while CAI grade and endoscope grade were evaluated. ResultsCompared with the control group, levels of MDA, LPO, NO, PGE2, TXB2 in blood and activity of MPO in col