Angiogenesis and non-small cell lung cancer correlation.docVIP

 PAGE \* MERGEFORMAT 14 Angiogenesis and non-small cell lung cancer correlation [Abstract] Objective To investigate microvessel density (MVD) and vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) Expression and prognostic value in NSCLC. Methods of immunohistochemistry in 43 patients with NSCLC paraffin sections MVD and VEGF expression. results in 43 cases of paraffin NSCLC, VEGF positive rate was 53.5% (23/43), and correlated with the MVD count. MVD count and the degree of histological NSCLC, T NM clinical stage, lymph node transfer has significant correlation. Univariate survival analysis showed that MVD, VEGF expression in NSCLC patients survival (OS) reduced (P lt;0.01); COX multivariate regression analysis showed that: MVD is an independent predictor of prognosis in NSCLC patients factor. after surgery in patients with high MVD expression of the relative risk of death is low expression of MVD in patients with 34.247 times (likelihood ratio test, P lt;0.01). Conclusions VEGF NSCLC, angiogenesis may play an important role; MVD and metastasis of NSCLC, may be a strong independent prognostic factors, MVD in NSCLC patients with poor prognosis high. [Keywords:] lung cancer; microvessel density; vascular endothelial growth factor [Abstract] Objective To investigate the relation between microvessel density (MVD) and vascular endothelial growth factor (VEGF) expression and the value of MVD and VEGF expression in non small cell lung cancer (NSCLC). Methods MVD and VEGF expression in tumor tissue from 43 cases of NSCLC were examined by immunohistochemistry methods. Results The positive expression of VEGF in 43 patients with NSCLC was 53.5% (23/43), and it was significantly correlated with MVD count. MVD count had obvious relationship with NSCLC histology differentiation, TNM phage, lymphatic metastasis. The positive expressions of VEGF and MVD predicated shorter overall survival (OS). MVD was an independent prognostic factor of