Angiopoietin2 in cervical cancer and cervical intraepithelial neoplasia and its clinical significance in.docVIP

 PAGE \* MERGEFORMAT 14 Angiopoietin2 in cervical cancer and cervical intraepithelial neoplasia and its clinical significance in [Abstract] Objective angiopoietin 2 (Angiopoietin 2, Ang 2) in cervical cancer in progress. Methods collected 50 cases of cervical squamous cell carcinoma ( a ~ a period) (SCC) and 50 cases of cervical intraepithelial neoplasia ( CIN) specimens, and 45 normal cervical tissues as control group; Immunohistochemical Ang 2 was detected in the expression of these three groups; detection of CD34 expression, microvascular density in each group count (MVD). Results (1) Ang 2 In the SCC, the positive expression rate of 79.6% in CIN, the positive expression rate of 26.7% in the control group, expression of 7.5%. SCC Ang 2 positive group was significantly higher than the CIN group and control group, CIN positive rate of was significantly higher (P lt;0.05). (2) SCC group was significantly higher than that of CIN MVD group and the control group, the difference was statistically significant (P lt;0.05). (3) SCC tissues, with the lower degree of differentiation , Ang 2 expression rate was significantly higher, statistically significant differences (P lt;0.05). (4) SCC and CIN tissues, MVD values and the expression of Ang 2 was a significant positive correlation (r = 0.61,0.52) . Conclusion Ang 2 and is closely related to angiogenesis, involved in the biological behavior of malignant tumors. [Keywords:] angiopoietin 2; microvessel density; cervical squamous cell carcinoma; cervical intraepithelial neoplasia In vivo, tumor angiogenesis by a variety of angiogenic factors in the regulation. Angiopoietin 2 (Ang 2) is in the process of angiogenesis plays an important role of the protein (1), main effect is to promote vascular remodeling in role during tumor angiogenesis significantly. In this study, immunohistochemical detection of cervical squamous cell carcinoma SP (SCC), cervical intraepithelial neoplasia (CIN) The expression of tissue Ang 2