Angioplasty restenosis and vascular remodeling.docVIP

 PAGE \* MERGEFORMAT 15 Angioplasty restenosis and vascular remodeling Keywords:: Angioplasty transluminal percutaneous coronary vascular remodeling in coronary artery disease Own reports of percutaneous transluminal coronary angioplasty (PTCA) has been the treatment of coronary heart disease had a tremendous impact, significantly reducing the incidence of coronary heart disease and mortality, so that the success rate of treatment of such patients from 67 hospital % to 88%. As the active use of antispasmodic drugs, anticoagulant drugs, thrombolytic therapy, and new mechanical devices, so that the acute PTCA significantly decreased the incidence of complications, so that restenosis problem has become a significant rise, due to restenosis based different standards to determine the current statistics restenosis rate of about 30% to 50% [1], a serious impediment to the further development of the PTCA patients. A pathological process of restenosis pTCA immediately after exposure due to subendothelial components, rapid emergence of platelet deposition, aggregation, internal injuries a few hours of local micro-thrombus formed on the surface [2]. Over the next few days, neutrophils, monocytes / macrophages and T-cell infiltration of damage region leading to inflammation, the mechanical stimulation allows intraoperative arterial smooth muscle cells in the middle stationary oncogene is activated, circulating blood and damage local platelets, inflammatory cells to produce vasoactive substances and growth factors to quiescent smooth muscle cells from the middle contractile phenotype to synthetic phenotype conversion, to intimal migration, proliferation and secretion of matrix the formation of neointimal hyperplasia at this time Local organizations were also activated metalloproteinases and accelerate the migration of smooth muscle cells [3]. After 4 weeks, neointimal proliferation of smooth muscle cells gradually cease, apoptosis frequency increased neointima in matrix