Angiogenesis inhibitor Canstatin joint nutmeg extract treatment Experimental study of tumor-bearing nude mice.docVIP

 PAGE \* MERGEFORMAT 8 Angiogenesis inhibitor Canstatin joint nutmeg extract treatment Experimental study of tumor-bearing nude mice 【Abstract】 Objective: To explore the joint canstatin cardamom extract on human gastric cancer cell line SGC  7901 gastric carcinoma model of tumor growth in nude mice. Methods: To establish nude mouse human gastric cancer orthotopic transplantation models, the model in nude mice were randomly divided into Canstatin group, nutmeg extract group, the combination treatment group, while the establishment of the control group, the volume of the in-situ cultivation and inhibitory rate of gastric cancer, tumor microvessel density were observed, line detection of apoptotic index. Results: Cardamom extract group, Canstatin group, combination therapy group the inhibition rates were 28.8%, 38.9%, 44.1%; nutmeg extract group, Canstatin group, combination therapy group and the control group of tumor microvessel density (MVD ) were 23.81 ± 8.15,21.50 ± 9.17,19.01 ± 7.15,29.45 ± 6.72. Conclusion: The Cardamom extracts Canstatin may inhibit tumor-bearing nude mice transplanted tumor growth, promote apoptosis of tumor cells and reduce tumor microvessel density, but the combined effect results are obvious. Keywords: tumor-bearing nude mice Canstatin nutmeg extract White cardamom is a ginger family plant, sexual Weixin temperature, in the final lung, spleen, stomach, with the dampness qi, warm in the antiemetic effect. Used to treat “stomach against”, “Ye Ge” and other symptoms. 1995 Japanese Pharmacopoeia Note (sixth to correct) the record of white cardamom treatment of gastric cancer. Canstatin was found in a new Kamphaus angiogenesis inhibitory factor [1,2], with a strong inhibition of vascular endothelial cell proliferation, migration and inducing endothelial cell apoptosis, inhibition of tumor cells. In this study, tumor-bearing nude mice with gastric cancer model to observe the joint Canstatin cardamom extract on human ga