Anti-apoptosis in the therapy of vitiligo.docVIP

 PAGE \* MERGEFORMAT 13 Anti-apoptosis in the therapy of vitiligo [Keywords:] Vitiligo; cell apoptosis Vitiligo is a common disease of the skin depigmentation, a large number of data indicate that skin lesions of patients with vitiligo melanocytes at the lack of existence. Histopathological evidence that the melanocytes of vitiligo lesions disappeared or at reduced [1], patients with vitiligo melanocyte destruction mechanism is not clear, but the pathological and some laboratory evidence that apoptosis can not be other than melanocytes in vitiligo destruction played a major role [2]. histopathology observed in patients with vitiligo melanocyte lesions disappeared or at reduced basal cells and their week has not been destroyed, which is consistent with the characteristics of apoptosis regulatory fine. large number of clinical and experimental study found that melanoma cell apoptosis in the pathogenesis of vitiligo play a very important role. Wang et al [3] Research by Smyth chicken melanocyte apoptosis in the destruction of the role of the Fluorescent terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) in situ cell detection withered death. that vitiligo Smyth chicken TUNEL + cells were significantly higher. the degree of apoptosis following the severity of melanin depigmentation changes, activities most of the pigment loss, suggesting that apoptosis of melanocytes and melanin depigmentation related. In addition to TUNEL staining, the use of cytotoxic T cells (CD8 +) or major histocompatibility complex - (MHC-) molecules to explore the double staining of infiltrating CD8 + lymphocytes and the relationship between the number of apoptotic cells . study found that normal pigment compared to the control, CD8 + and MHC type cells in the Smyth chicken place visible depigmentation spots the first 2 to 4 weeks is elevated, and the direct and TUNEL + cell number, in either prior to the onset, when the disease or hypopigmentation in the proc