Anti-apoptosis gene Survivin in Colorectal Cancer Research Relations.docVIP

 PAGE \* MERGEFORMAT 18 Anti-apoptosis gene Survivin in Colorectal Cancer Research Relations [Abstract] Survivin gene identified as the strongest current of apoptosis suppressor gene, is currently a research focus. This paper introduces the Survivin gene structure, their biological function has been studied, and then analyzes the Survivin gene and colorectal cancer, the relationship between the occurrence and development, and ultimately make Survivin targeted therapy methods, and Survivin in colorectal cancer and colorectal cancer prognosis. [Keywords:] Survivin, colorectal cancer, shear isomers, targeted therapy In Europe and other developed countries and regions, the incidence of colorectal cancer rate jumped to the first 2 to 3, in most parts of China, the incidence rate of malignant tumors accounted for 4 to 5. Cancer surgery is the primary treatment of colorectal cancer, but with the development of molecular biology, the treatment will target the tumor as a new treatment to clinical use, thus increasing survival rate. Survivin gene is found the strongest inhibitor of apoptosis gene, a highly specific tissue distribution and tumor development and are closely related. Therefore, the correlation of Survivin gene in colorectal cancer diagnosis, treatment and prognosis are of great value. This different isomers of the main shear effects on cancer and targeted therapy of colorectal cancer Survivin literature research work carried out. 1 Survivin gene structure and biological effects 1.1 Survivin gene in the molecular structure of inhibitor of apoptosis proteins (Inhibitor of Apoptosis Family of protein IAPs, including NAIP, c-IAP-1, c-IAP-2, XIAP, BRUGUE, Livin and Survivin 7 members. Which, Survivin in 1997 Altier effector cells by using protease receptor 1 (effector cell protease receptor 1, EPR-1) cDNA library from the human gene was first isolated hybrid screening. Survivin gene is located on human chromosome 17q25, full-length 14.7 kb, the co