Anti-CD20 monoclonal antibody treatment of refractory autoimmune hemolytic anemia.docVIP

 PAGE \* MERGEFORMAT 8 Anti-CD20 monoclonal antibody treatment of refractory autoimmune hemolytic anemia Author: Wang Li Wei Li Jianyong Xie Xiaoyan Xu Rui-Lan Sheng Abstract preliminary observation of this study of anti-CD20 monoclonal antibody rituximab (rituximab) for the treatment of refractory autoimmune hemolytic anemia (AIHA) of the efficacy and safety. Of 1 were treated with corticosteroids, splenectomy ineffective AIHA patients, using monoclonal antibody rituximab, 375 mg/m2, every week a meeting, a total of four times, observe and monitor changes in symptoms of hemolysis hemoglobin (Hb) levels of and other test indicators, whether the adverse reactions were observed. The results showed that the first 11 days after treatment of lactate dehydrogenase (LDH), total bilirubin (TBIL), direct bilirubin (IBIL) gradually decreased, the first 45 days fell to normal range; 25 days after the first dose of treatment Hb higher level than before treatment to 95-100 g / L or more. 4 more than a month after treatment, the patient remains in remission. Course of treatment, no obvious adverse reactions. Conclusion: Anti-CD20 monoclonal antibody rituximab for the treatment of refractory autoimmune hemolytic anemia is effective and safe. Keywords: anti-CD20 monoclonal antibody; rituximab; hemolytic anemia; refractory autoimmune hemolytic anemia Anti  CD20 Monoclonal Antibody for the Treatment of Refractory Autoimmune Hemolytic Anemia Abstract To observe the therapeutic effect and safety of rituximab (anti  CD20 monoclonal antibody) in the treatment of refractory autoimmune hemolytic anemia (AIHA). One AIHA patient refractory to corticosteriod and splenectomy was treated with rituximab, 375 mg/m2 weekly for four times . Her hemolytic symptoms, adverse effects, hemoglobin (Hb) concertration and other laboratory data were monitored. The results showed that concentration of lactic dehydrogenase (LDH), total bilirubin (TBIL) and indirect bilir