Anti-tumor mechanism of matrine alkaloids Progress.docVIP

 PAGE \* MERGEFORMAT 16 Anti-tumor mechanism of matrine alkaloids Progress Of: Li, Hai-Fang Li, Xiao Yuan, Wang Zhibin [Keywords:] Sophora, alkaloids, anti-tumor, review For the leguminous plant Sophora flavescens Sophora flavescens Aitl dry root, with heat dampness, insecticide, diuretic function. Modern research shows that matrine contains alkaloids, flavonoids, saponins, volatile oil and a variety of chemical constituents , which is divided into matrine-type alkaloid, cytisine type songoricum lupine base type and base type, such as different types of alkaloids. In recent years, in vivo and in vitro experiments on the extraction and separation of alkaloids, Pharmacological and clinical research has made great progress. This is the basic framework of alkaloids Kuinuolixi pyridine (Quinolizidime), with asthma, anti-inflammatory, anti-virus, anti-inflammatory, improve immune function, anti-tumor and other aspects of pharmacological activity. which matrine and oxymatrine the strongest anti-tumor activity [1]. Chinese medicine matrine and matrine oxymatrine is the main active in the anti-tumor components, widely found in leguminous plants Sophora, Sophora alopecuroides and Sophora Root. Studies show that matrine and oxymatrine by inhibiting tumor cell proliferation, metastasis, and to induce apoptosis in normal cell differentiation, inhibit cell adhesion and vascular metastasis, immune, and the inhibition of oncogene and proto-oncogene expression, and has anti-tumor activity, are on the matrine and anti-tumor effect of oxymatrine brief summary of local production. 1 inhibited tumor cell proliferation Matrine and matrine can inhibit the oxidation of a variety of tumor cell proliferation, and its inhibitory effect and time, concentration. Studies show that matrine can inhibit the human hepatoma cell line HepG2, SMMC-7721 and human chronic K562 myeloid leukemia cell line proliferation, MTT test showed that: matrine on HepG2 and K562 inhibited dose