Apoptosis and myocardial ischemia-reperfusion injury.docVIP

 PAGE \* MERGEFORMAT 22 Apoptosis and myocardial ischemia-reperfusion injury Traditional view is usually the myocardial ischemia-reperfusion injury were divided into 3 types, namely, myocardial stunning, reperfusion arrhythmia and myocardial necrosis, and that necrosis is the only way to cardiac cell death. As the molecular study of cardiovascular disease continues to develop, in recent years, cardiac cells also confirmed the existence of other forms of death - apoptosis (apoptosis), and in myocardial ischemia-reperfusion injury in the pathophysiological process play an important role in [1]. This paper reviewed the progress in this regard, is designed to explore the myocardial ischemia-reperfusion injury and effective measures to provide information. 1, myocardial ischemia-reperfusion experimental evidence for apoptosis Although there are a number of studies have shown that myocardial ischemia-reperfusion can induce apoptosis, but on the apoptosis is induced by ischemic injury or by reperfusion injury induced by problems remain controversial. Kajstura et al [2] found that in rat myocardial ischemia and immediately after 2 ~ 3h apoptotic cells after ischemia and 4.5h of the number of apoptotic cells reached a peak and then gradually reduced. Using in vivo rat model of myocardial ischemia-reperfusion found that continuous ischemia or ischemia and 45min reperfusion 2.25h both 1h production of apoptotic cells, and as the reperfusion time prolonged, the number of apoptotic cells increased [ 3]. And the study results to differ, using in vivo rabbit model of myocardial ischemia-reperfusion found that ischemia 30min, 4.5h and 4h of ischemia and 5min reperfusion myocardial cells were not apoptotic phenomenon, 30min ischemia and 4h reperfusion myocardial cells appeared in the apoptosis, so that apoptosis of myocardial ischemia-reperfusion injury in a special reaction [4]. Zhao et al [5] using canine coronary artery with complete obstruction 7h or o