Antigen processing and presenting.docVIP

 PAGE \* MERGEFORMAT 5 Antigen processing and presenting Keywords:: antigen 1, antigen capture and processing Accessory cells can capture antigens through a variety of parties, such as phagocytosis (on the same kinds of cells or bacteria and other large particles) and pinocytosis role (for viruses and other tiny particles or molecules), etc.. This phagocytic and pinocytotic role of the non-antigen-specific, possibly identifying the mechanism is the phagocytic cells with engulfed particles were differences between the surface hydrophilic. There are also receptor-mediated proactive role, which is a weak force of accessory cells engulfed the main way to capture antigen, for example, can take advantage of B-cell antigen receptor (surface immunoglobulin) and the corresponding antigen-specific binding, and antigen within the treatment. These capture the way neutrophil phagocytosis (see Chapter VIII) similar. Associated with antigen processing (antigenprocessing) refers to the natural antigen, accessory cells into the TH cell recognition may be the form of process; This process involves antigen variability, degradation and modification, etc.. For example, in the phagocytosis of bacteria by lysozyme digestion and degradation of the body, will effectively be finishing the antigen peptide modification, and class I molecules with MHC Ⅱ connected, and then transported to the cell membrane. Classes with MHC Ⅱ molecules are protein antigens; polysaccharides and lipids are not easy to MHC Ⅱ type molecular connectivity, can hardly be TH cell recognition, and therefore as something other than a good immunogen; but sometimes it can induce antibodies of the immune response. Second, antigen presenting Antigen-presenting (antigenpresentation) is his assistant, helper T cells, cells to demonstrate antigen and MHC Ⅱ type of molecular compound, and make the process of integration with the TCR. This process is almost all the necessary steps in lymphocyte activation. Antigen