Artemether on BALB - c mice with CT-26 colorectal cancer tumor suppressor role of the.docVIP

 PAGE \* MERGEFORMAT 12 Artemether on BALB / c mice with CT-26 colorectal cancer tumor suppressor role of the Author: Wu Zhiping Gao Xi Cai Yong-Gui Wu Cheng-wei Hu Wei Zhu Qishun Abstract [Objective] To investigate the artemether (Artemether) of BALB / c mice with CT-26 colorectal cancer anti-tumor effect. [Methods] BALB / c mice were inoculated subcutaneously with CT-26 colorectal carcinoma cells (2 × 106) 48 pieces evenly divided male and female; were randomly divided into six groups of eight, respectively, for low-dose (33.3mg/kg) , medium dose (50mg/kg), high-dose (66.6mg/kg) and medium-dose (50mg/kg) iron (1.5mg/kg) group, positive control group, cisplatin (5mg/kg), blank control group, To an equal volume of saline. In addition to intra-abdominal injection of cisplatin, the other groups were gavage method. [Results] oral artemether low, medium and high dose and the dose of iron on the BALB / c mice with CT-26 colorectal tumor inhibition rates were as follows: 42.3%, 51.4%, 52.0%, 53.5%. [Conclusion] In a certain dose range, oral artemether in mice CT-26 significantly inhibited colorectal cancer; artemether combination with iron has a certain synergy. Anti-tumor Effect of Artemether in CT-26 Colorectal Cancer Bearing BALB / c Mice Abstract: [Purpose] To explore the anti-tumor effect of Artemether in CT-26 colorectal cancer bearing BALB / c mice. [Methods] Forty-eight BALB / c mice (24 male and 24 female) subcutaneous planted with CT-26 colorectal cancer cell (2 × 106) were randomly divided into 6 groups (8 mice in each): low dose group, 33.3mg/kg; middle dose group, 50mg/kg; high dose group, 66.6mg/kg; Artemether 50mg/kg plus ferralia 1.5mg/kg; positive control group, DDP 5mg/kg; and blank control group, same volume of normal saline. All were administrated, excepted DDP intraperitoneally. [Results] Inhibitive rates of Artemether by oral at dosages of low, middle and high were 42.3%, 51.4% and 52.0%, respectively. [Conclusion