Attenuated Salmonella vector in gene therapy research in progress.docVIP

 PAGE \* MERGEFORMAT 16 Attenuated Salmonella vector in gene therapy research in progress [Abstract] Clinical application of gene therapy in the key problem is to choose a suitable gene vector. This vector itself toxic side effects, and can target tumor tissue. Most human solid tumors contain hypoxic and necrotic areas, or specifically as part of provide a suitable anaerobic conditions for breeding. Attenuated Salmonella reported in tumor hypoxia zone in the growth and reproduction, leading to tumor cell death, inhibition of tumor growth. Therefore, this paper attenuated Salmonella vector in cancer gene therapy applications were reviewed. [Keywords:] bacterial DNA vector, gene therapy, Salmonella, tumor; Summary Abstract: Gene therapy for cancer treatment represents a promising approach that has shown selectivity and efficacy in clinical trials.Attenuated Salmonella strains capable of both selective amplification within tumors and expression of effector genes encoding therapeutic proteins are probably the most promising.In this review, we will describe the gene delivery system based on the use of attenuated Salmonella strains. Keywords:: bacterial DNA transfer; gene therapy; Salmonella, tumor Experimental gene therapy in cancer research and clinical treatment of selective and effective. Gene therapy in clinical application is important challenges encountered in the development of appropriate DNA carrier, so that the carrier has the greatest effectiveness and minimal toxicity. The traditional There are two types of DNA vectors: viral vectors and non-viral vectors, which include chemical compounds, or naked DNA. recently found that carriers of bacteria, including Clostridia, attenuated Listeria monocytogenes bacteria, Shigella and Yersinia, invasive E. coli can be used for gene therapy [12]. Cancer gene therapy using tumor vaccine research or suicide gene therapy [3]. In this paper, attenuated Salmonella vector in gene therapy do reviewed. 1 Int