Baicalin on atherosclerosis of thrombin activated fibrinolysis inhibitor in rats and blood lipids coagulation and fibrinolysis indexes.docVIP

 PAGE \* MERGEFORMAT 14 Baicalin on atherosclerosis of thrombin activated fibrinolysis inhibitor in rats and blood lipids coagulation and fibrinolysis indexes Of: the Xiang-qun Xin Chen Huan-qin Ma Wenjian effective safety [Abstract] Objective To observe the effect of baicalin on atherosclerosis (AS) rat model of thrombin activated fibrinolysis inhibitor (TAFI) levels and blood lipids, coagulation and fibrinolysis indicators of the impact of baicalin in the process of intervention mechanisms AS . Methods 40 healthy male Wistar rats were randomly divided into normal control group, model group, baicalin treatment group, simvastatin group, n = 10. the normal control group were fed with normal diet and the remaining 3 groups at the given high fat diet feeding operation based uplink aortic balloon injury, feeding 4 months to rat AS model. using automatic biochemical analyzer plasma total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL -C), low density lipoprotein cholesterol (LDL-C), with automatic coagulometer prothrombin time (PT), activated partial thromboplastin time (APTT), FIB (Fib), chromogenic Determination of plasma TAFI physical activity. Results Compared with normal control group, other groups of rats TC, TG, LDL-C, Fib and TAFI activity were significantly increased (P lt;0.01 or the P lt;0.05), PT, APTT was significantly shorter (P lt;0.01 or P lt;0.05); end of the experiment compared with model group, baicalin treatment group and simvastatin group, TC, TG, LDL-C, Fib and TAFI activity was significantly lower than the model group (P lt;0.01 or P lt;0.05), PT, APTT significantly prolonged (P lt;0.01 or P lt;0.05); with the simvastatin group, baicalin treatment group TC, TG, LDL-C, Fib, PT, APTT improved to a lesser extent (P lt;0.05), while no significant statistical difference between TAFI activity (Pgt; 0.05). Conclusion baicalin possibly through lowering blood pressure, improve the balance of coagulation and fibrino