Bistorta n-butanol extract on isolated guinea pig left atrial excitability and functional refractory period of.docVIP

 PAGE \* MERGEFORMAT 20 Bistorta n-butanol extract on isolated guinea pig left atrial excitability and functional refractory period of 【Abstract】 Objective To observe the boxing reference n-butanol extract on isolated guinea pig left atrial excitability and functional refractory period, and to explore its mechanism. Methods Determination of isolated guinea pig left atrium bistorta n-butanol extract of its intensity - time curves and functional refractory period studied. Results bistorta n-butanol extract of isolated guinea pig left atrium can intensity - time curves upward, functional refractory period shortened, and there is a clear dose-dependent. Conclusion bistorta n-butanol extract can significantly reduce the excitability of the left atrium and shorten the functional refractory period, and there is a clear dose-dependent. The mechanism may be through inhibiting the myocardial cell membrane voltage-dependent sodium channels and the promotion of three-phase K outflow effects. Keywords: bistorta n-butanol extract of left atrial functional refractory period of excitatory Abstract: ObjectiveTo observe the effect of Polygonum Bistorla’s n-Butyl alcohol extract (PBNA) on excitability and functional refractory period (FRP) of excised guinea pig pulmonary atrium and to discuss its mechanism. MethodsThe effect of PBNA on excised guinea pig pulmonary atrium was investigated by intensity-time curve and FRP. ResultsPBNA upper-shifted intensity-time curve and shortened FRP on excised pulmonary atrium which was in proportion with the extract’s dosage. ConclusionPBNA has an effect of reducing excitability and shortening FRP of excised pulmonary atrium in a manner of dosage  dependent. It may work through inhibiting membrane voltage  dependent Na channel and promoting an outflow K with cardiac muscle cells. Keywords:: Polygonum Bistorla’s n-Butyl alcohol extract; Pulmonary atrium; Excitability; Functional refractory period Bistor