Children infected with HIV1 CD3dimCD56 + cells and its receptor in the research.docVIP

 PAGE \* MERGEFORMAT 14 Children infected with HIV1 CD3dimCD56 + cells and its receptor in the research Study: More Feng Fu Zhaojun Li Xu Xiaoqin Ding Hao Sha Ping Ping, Yang Hai-Tao Hou Yayi has tin [Abstract] Objective: To study the human immunodeficiency virus 1 (HIV 1) infection of children CD3dimCD56 + cells in vivo and some changes in cell receptor. Methods: Collection of 11 cases of confirmed HIV 1 and 10 cases of children infected with HIV 1 antibody negative healthy children anticoagulant whole blood flow cytometry on CD3dimCD56 + cell number and cell receptor expression on the part of the determination. Results: HIV 1 infected children CD3dimCD56 + cells were significantly more than the number of healthy children (P lt;0.01, HIV 1 infected children compared with healthy children, CD16 remained unchanged (Pgt; 0.05, NKp30, NKG2D, KIR2DL1, and CD244 expression was significantly increased (P lt;0.01, NKp44, NKp46, KIR3DL1, and NTB A expression was significantly increased ( P lt;0.05, NKp80 expression was significantly lower (P lt;0.01. Conclusion: HIV 1 infected children CD3dimCD56 + cells was significantly more than the number of healthy children, and the cells receptor expression change dramatically. [Keywords:] human immunodeficiency virus 1 infection in children who CD3dimCD56 + cell receptor Abstract: Objective To study the changes of CD3dimCD56 + cell and its receptors in HIV 1 infected children. Methods Blood samples from 11 HIV 1 infected children and 10 healthy children were collected in EDTA coated vacutainer.The number of CD3dimCD56 + cells and the expression of its receptors were determined by flow cytometry. Results The number of CD3dimCD56 + cell in HIV 1 infected children was higher than that in healthy children. Compared with healthy children, no change was found in the expression of CD16 receptor in HIV 1 infected children, but the expression of NKp30, NKG2D, KIR2DL1 and CD244 receptors was significantly increased (P lt;0.0